Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1475
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dc.contributor49237es_ES
dc.coverage.spatialGlobales_ES
dc.creatorLópez Verdín, Sandra-
dc.creatorSoto Ávila, Juan José-
dc.creatorZamora Pérez, Ana Lourdes-
dc.creatorLzalde Ramos, Blanca Patricia-
dc.creatorMartínez Fierro, Margarita de la Luz-
dc.creatorGonzález González, Rogelio-
dc.creatorMolina Frechero, Nelly-
dc.creatorIsiordia Espinoza, Mario Alberto-
dc.creatorBologna Molina, Ronell-
dc.date.accessioned2020-03-31T20:47:41Z-
dc.date.available2020-03-31T20:47:41Z-
dc.date.issued2017-11-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1698-4447es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1475-
dc.description.abstractBackground: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Methods: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. Results: sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin expression was statistically significantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse relationship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). Conclusions: The results suggest that sE-cadherin levels are significantly increased in patients with oral cancer and that its low expression within the membrane as well as the progression of the disease appear to be inversely associated with levels of sE-cadherin in the saliva.es_ES
dc.language.isoenges_ES
dc.publisherSociedad Española de Medicina Orales_ES
dc.relationhttps://www.ncbi.nlm.nih.gov/pubmed/29053653es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceRevista Medicina oral, patología oral y cirugía bucal, Vol. 22, No. 6, noviembre de 2017,es_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.otherE-cadher.ines_ES
dc.subject.othersalivaes_ES
dc.subject.otheroral canceres_ES
dc.titlePatients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the salivaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- Doc. en Ing. y Tec. Aplicada

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