Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1477
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dc.contributor49237es_ES
dc.coverage.spatialGlobales_ES
dc.creatorMontes Galindo, Daniel-
dc.creatorEspiritu Mojarro, Ana-
dc.creatorMelnikov, Valery-
dc.creatorMoy Lopez, Norma-
dc.creatorSoriano Hernandez, Alejandro-
dc.creatorGalván Salazar, Héctor-
dc.creatorGuzmán Muñíz, Jorge-
dc.creatorGuzmán Esquivel, José-
dc.creatorMartínez Fierro, Margarita de la Luz-
dc.creatorRodríguez Sánchez, Iram Pablo-
dc.creatorPaz Michel, Brenda-
dc.creatorZaizar Fregoso, Héctor-
dc.creatorSánchez Ramírez, Carmen-
dc.creatorRamírez Flores, Mario-
dc.creatorDelgado Enciso, Iván-
dc.date.accessioned2020-03-31T20:48:08Z-
dc.date.available2020-03-31T20:48:08Z-
dc.date.issued2019-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn0304-8608es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1477-
dc.description.abstractAdenovirus 5 (Ad-5) infection is a common cause of acute respiratory infections and the main vector used in gene therapy. There are few studies on the relationship of Ad-5 to obesity. In the present study, we evaluated the chronic effects of Ad-5 infection on golden (Syrian) hamsters fed either a balanced diet (BD) or a high-fat diet (HFD). After a single inoculation with Ad-5 (1 × 107 pfu), the body weight of the animals was measured weekly. Medium-term (22 weeks) serum biochemical analyses and long-term (44 weeks) liver morphology, adiposity, and locomotive functionality (movement velocity) assessments were carried out. In the animals fed the BD, adenovirus infection produced hyperglycemia and hyperlipidemia. In the long term, it produced a 57% increase in epididymal pad fat and a 30% body weight gain compared with uninoculated animals. In addition, morphological changes related to non-alcoholic fatty liver disease (NAFLD) were observed. The animals fed the HFD had similar but more severe changes. In addition, the hamsters presented an obesity paradox: at the end of the study, the animals that had the most morphological and functional changes (significantly reduced movement velocity) had the lowest body weight. Despite the fact that an HFD appears to be a more harmful factor in the long term than adenovirus infection alone, infection could increase the severity of harmful effects in individuals with an HFD. Epidemiological studies are needed to evaluate the effect of adenovirus as a precursor of chronic liver and cardiovascular diseases, including the chronic effects of gene therapy.es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relationhttp://agris.fao.org/agris-search/search.do?recordID=US201900175953es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceArchives of virology, Vol. 164, No. 3, enero de 2019, pp. 775-786es_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.otherAdenoviruses_ES
dc.subject.otherobesityes_ES
dc.subject.otherhamsterses_ES
dc.titleAdenovirus 5 produces obesity and adverse metabolic, morphological, and functional changes in the long term in animals fed a balanced diet or a high‑fat diet: a study on hamsterses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- Doc. en Ing. y Tec. Aplicada

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