Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1480
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dc.contributor49237es_ES
dc.coverage.spatialGlobales_ES
dc.creatorPérez Ibave, Diana Cristina-
dc.creatorGonzález Álvarez, Rafael-
dc.creatorMartínez Fierro, Margarita de la Luz-
dc.creatorRuíz Aima, Gabriel-
dc.creatorLuna Muñoz, Maricela-
dc.creatorMartínez de Villareal, Laura Elía-
dc.creatorGarza Rodríguez, María de Lourdes-
dc.creatorReséndez Pérez, Diana-
dc.creatorMohamed Noriega, Jibran-
dc.creatorGarza Guajardo, Raquel-
dc.creatorBautista de Lucio, Victor Manuel-
dc.creatorMohamed Noriega, Karim-
dc.creatorBarbosa Quintana, Oralia-
dc.creatorArámburo de la Hoz, Carlos-
dc.creatorBarrera Saldaña, Hugo Alberto-
dc.creatorRodríguez Sánchez, Iram Pablo-
dc.date.accessioned2020-03-31T20:49:18Z-
dc.date.available2020-03-31T20:49:18Z-
dc.date.issued2016-11-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn0717-6287es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/1480-
dc.description.abstractBackground: The olfactomedin‑like domain (OLFML) is present in at least four families of proteins, including OLFML2A and OLFML2B, which are expressed in adult rat retina cells. However, no expression of their orthologous has ever been reported in human and baboon. Objective: The aim of this study was to investigate the expression of OLFML2A and OLFML2B in ocular tissues of baboons (Papio hamadryas) and humans, as a key to elucidate OLFML function in eye physiology. Methods: OLFML2A and OLFML2B cDNA detection in ocular tissues of these species was performed by RT‑PCR. The amplicons were cloned and sequenced, phylogenetically analyzed and their proteins products were confirmed by immunofluorescence assays. Results: OLFML2A and OLFML2B transcripts were found in human cornea, lens and retina and in baboon cornea, lens, iris and retina. The baboon OLFML2A and OLFML2B ORF sequences have 96% similarity with their human’s orthologous. OLFML2A and OLFML2B evolution fits the hypothesis of purifying selection. Phylogenetic analysis shows clear orthology in OLFML2A genes, while OLFML2B orthology is not clear. Conclusions: Expression of OLFML2A and OLFML2B in human and baboon ocular tissues, including their high simi‑ larity, make the baboon a powerful model to deduce the physiological and/or metabolic function of these proteins in the eye.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relationhttps://www.ncbi.nlm.nih.gov/pubmed/27821182es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceBiological Research, Vol. 8, No 49, Nov. 2016, pp. 44es_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.otherOlfactomedines_ES
dc.subject.otherEyees_ES
dc.subject.otherOld world monkeyes_ES
dc.subject.otherBaboones_ES
dc.subject.otherOLFML2es_ES
dc.titleOlfactomedin‑like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon)es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- Doc. en Ing. y Tec. Aplicada

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