Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2170
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dc.contributor4494es_ES
dc.contributor84378es_ES
dc.contributor243523es_ES
dc.contributor4495es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-3403-9849-
dc.coverage.spatialGlobales_ES
dc.creatorHerrera Esparza, Rafael-
dc.creatorVillalobos, Ricardo-
dc.creatorBollain y Goytia, Juan José-
dc.creatorRamírez Sandoval, Roxana-
dc.creatorSánchez Rodríguez, Sergio-
dc.creatorPacheco Tovar, María Guadalupe-
dc.creatorAvalos Díaz, Esperanza del Refugio-
dc.date.accessioned2020-12-03T14:52:54Z-
dc.date.available2020-12-03T14:52:54Z-
dc.date.issued2006-12-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1740-2530es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2170-
dc.identifier.urihttps://doi.org/10.48779/5maj-dy31-
dc.description.abstractIn subacute cutaneous lupus eryhematosus (SCLE) the cutaneous antigens constitute the main source of Ro and La autoantigens. The aim of this investigation was to demonstrate if UV light increases the availability of Ro autoantigen in the skin, also the blocking effect of Ac-DEVD-CMK a caspase inhibitor was assessed. For this purpose newborn Balb/c mice were UVB irradiated (5–30 mJ/cm2) equivalent to a moderate to severe sunburn. Animals were injected with monoclonal anti-Roantibodies from SCLE patients. Apoptosis was also induced by anti-Fas antibody injection. Skin samples were examined by direct immunofluoresence, by TUNEL, and the expression of caspase 3 by RT-PCR. Major findings of present studies were: 1. UVB irradiation and anti-Fas induced apoptosis of keratinocytes. 2. Apoptosis redistribute the Ro antigen on cell surface and is better triggered by Ro antibody. 3. The caspase 3 inhibitor Ac-DEVD-CMK decreases the availability of Ro autoantigen in epidermis and prevents deposition of anti-Ro. In conclusion, the caspase pathway would be blocked to avoid anti-Ro deposition along skin; this finding would be a prospect in the treatment of SCLE patients.es_ES
dc.language.isospaes_ES
dc.publisherTaylor & Francises_ES
dc.relationhttps://www.hindawi.com/journals/jir/2006/939015/es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceClinical & Developmental Immunology, Junio–Diciembre 2006; 13(2–4): 163–166es_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.otherLupuses_ES
dc.subject.otherRoes_ES
dc.subject.otherAntigenes_ES
dc.subject.otherApoptosises_ES
dc.subject.otherCutaneous Lupuses_ES
dc.titleApoptosis and redistribution of the Ro autoantigen in Balb/c mouse like in subacute cutaneous lupus erythematosuses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- UA Medicina

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