Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2542
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dc.contributor208395es_ES
dc.contributor268446es_ES
dc.contributor49237es_ES
dc.contributor.other0000-0003-2124-2036es_ES
dc.coverage.spatialGlobales_ES
dc.creatorFernández Ruiz, Julio C.-
dc.creatorGalindo De Ávila, Julia C.-
dc.creatorMartínez Fierro, Margarita-
dc.creatorGarza Veloz, Idalia-
dc.creatorCervantes Villagrana, Alberto Rafael-
dc.creatorValtierra Alvarado, Mónica A.-
dc.creatorSerrano, Carmen J.-
dc.creatorGarcía Hernández, Mariana H.-
dc.creatorEnciso Moreno, José A.-
dc.creatorCastañeda Delgado, Julio E.-
dc.date.accessioned2021-05-31T19:11:01Z-
dc.date.available2021-05-31T19:11:01Z-
dc.date.issued2019-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn23146745es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2542-
dc.description.abstractType 2 diabetes mellitus (DM2) is strongly associated with other comorbidities such as obesity, atherosclerosis, and hypertension. Obesity is associated with sustained low-grade inflammatory response due to the production of proinflammatory cytokines. This inflammatory process promotes the differentiation of some myeloid cells, including myeloid-derived suppressor cells (MDSCs). In this study, two groups of individuals were included: DM2 patients and non-DM2 individuals with similar characteristics. Immunolabeling of CD15+ CD14- and CD33+ HLA-DR-/low was performed from whole peripheral blood, and samples were analyzed by flow cytometry, and frequencies of MDSCs and the relationship of these with clinical variables, cytokine profile (measured by cytometric bead array), and anthropometric variables were analyzed. The frequency of CD33+ HLA-DR-/low MDSCs (that produce IL-10 and TGF-β, according to an intracellular detection) is higher in patients with DM2 (P < 0:05), and there is a positive correlation between the frequency of CD15+ CD14- and CD33+ HLA-DR-/low MDSC phenotypes. DM2 patients have an increased concentration of serum IL-5 (P < 0:05). Also, a negative correlation between the frequency of CD15+CD14- MDSCs and LDL cholesterol was found. Our group of DM2 patients have an increased frequency of mononuclear MDSC CD33+ HLA-DR-/low that produce TGF-β and IL-10. These cytokines have been associated with immune modulation and reduced T cell responses. DM2 and non-DM2 subjects show a similar cytokine profile, but the DM2 patients have anincreased concentration of IL-5.es_ES
dc.language.isoenges_ES
dc.publisherHindawies_ES
dc.relationhttps://www.hindawi.com/journals/jdr/2019/1568457/es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceJournal of Diabetes Research Vol. 2019, pp. 1-10es_ES
dc.subject.classificationMEDICINA Y CIENCIAS DE LA SALUD [3]es_ES
dc.subject.otherMyeloid-Derived Suppressor Cellses_ES
dc.subject.otherDiabeticses_ES
dc.subject.otherSubjects with Arterial Hypertensiones_ES
dc.titleMyeloid-Derived Suppressor Cells Show Different Frequencies in Diabetics and Subjects with Arterial Hypertensiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química



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