Please use this identifier to cite or link to this item:
http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2548
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | 208395 | es_ES |
dc.contributor.other | 0000-0002-0504-2299 | es_ES |
dc.contributor.other | 0000-0001-7112-3233 | es_ES |
dc.contributor.other | 0000-0001-8012-7041 | es_ES |
dc.contributor.other | 0000-0002-1068-603X | es_ES |
dc.coverage.spatial | Global | es_ES |
dc.creator | Rivas Santiago, Cesar | - |
dc.creator | González Curiel, Irma | - |
dc.creator | Zarazua, Sergio | - |
dc.creator | Murgu, Michael | - |
dc.creator | Ruiz Cardona, Alonso | - |
dc.creator | Lazalde, Blanca | - |
dc.creator | Lara Ramírez, Edgar E. | - |
dc.creator | Vázquez, Edgar | - |
dc.creator | Castañeda Delgado, Julio Enrique | - |
dc.creator | Rivas Santiago, Bruno | - |
dc.creator | López, Jesús Adrián | - |
dc.creator | Cervantes Villagrana, Alberto R. | - |
dc.creator | López Hernández, Yamile | - |
dc.date.accessioned | 2021-06-01T13:56:47Z | - |
dc.date.available | 2021-06-01T13:56:47Z | - |
dc.date.issued | 2019 | - |
dc.identifier | info:eu-repo/semantics/publishedVersion | es_ES |
dc.identifier.issn | 2314-6141 | es_ES |
dc.identifier.uri | http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2548 | - |
dc.description.abstract | Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, suchas type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm). Significant differences in the levels of certain identified lyso-phospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes. Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls. Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen’s disease, and kidney, liver, bladder, and lung cancer). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Hindawi | es_ES |
dc.relation | https://www.hindawi.com/journals/bmri/2019/4978018/ | es_ES |
dc.relation.uri | generalPublic | es_ES |
dc.rights | Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.source | BioMed Research International Vol. 2019 PP. 1-17 | es_ES |
dc.subject.classification | BIOLOGIA Y QUIMICA [2] | es_ES |
dc.subject.other | Lipid Metabolism Alterations | es_ES |
dc.subject.other | Arsenic | es_ES |
dc.title | Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
Appears in Collections: | *Documentos Académicos*-- M. en Ciencias y Tecnología Química |
Files in This Item:
File | Description | Size | Format | |
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Lipid Metabolism Alterations in a Rat Model of Chronic and.pdf | 3,18 MB | Adobe PDF | View/Open |
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