Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2596
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dc.contributor46461es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-1995-1696-
dc.coverage.spatialMéxicoes_ES
dc.creatorGalaviz Hernández, Carlos-
dc.creatorLazalde Ramos, Blanca Patricia-
dc.creatorMartínez Cortéz, Gabriela-
dc.creatorRangel Villalobos, Héctor-
dc.creatorMartínez Aguilar, Gerardo-
dc.creatorLeal Ugarte, Evelia-
dc.creatorPeralta Leal, Valeria-
dc.creatorGonzález Rentería, Siblie-
dc.creatorRodríguez Moran, Martha-
dc.creatorJaquez Chairez, Francia-
dc.creatorGuerrero Romero, Fernando-
dc.creatorSosa Macías, Martha-
dc.date.accessioned2021-06-17T17:38:57Z-
dc.date.available2021-06-17T17:38:57Z-
dc.date.issued2020-11-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1945-0265es_ES
dc.identifier.issn1945-0257es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2596-
dc.identifier.urihttps://doi.org/10.48779/365m-7j95-
dc.description.abstractAims: The 5HTT gene has been associated with obesity; this study aimed to determine the association between L- and S-alleles at the 5HTTLPR polymorphism with obesity in indigenous Mexican populations. Materials and Methods: A total of 362 individuals, 289 belonging to eight Native American (NA) groups; 40 Mexican mestizos; and 33 Caucasian Mennonites were enrolled in a cross-sectional study. High (≥90%) and low (<90%) NA ancestry was molecularly determined. A body mass index >30 kg/m2 was considered as obese. The L- and S-alleles of the 5HTTLPR locus were identified by PCR; the association between alleles and obesity was performed by logistic regression analysis. Results: A significantly lower prevalence of obesity (35%) was observed in participants from communities with high NA ancestry (p < 0.005). Under a dominant heritance model the L-allele was associated with obesity in women with high NA ancestry (odds ratio [OR] 7.27; 95% confidence interval [CI] 1.6–32.5; p = 0.009) but not in women with low NA ancestry (OR 0.83; 95% CI 0.3–2.2; p = 0.71); no association was observed in men. Conclusion:Our results suggest that the 5HTTLPR L-allele is a risk factor for developing obesity in Mexican women with high NA ancestry (≥90%).es_ES
dc.language.isospaes_ES
dc.publisherMary Ann Liebert, Inc.es_ES
dc.relationhttps://www.liebertpub.com/doi/10.1089/gtmb.2020.0068es_ES
dc.relation.ispartofhttp://doi.org/10.1089/gtmb.2020.0068es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceGenetic Testing and Molecular BiomarkersVol. 24, No. 11es_ES
dc.subject.classificationBIOLOGIA Y QUIMICA [2]es_ES
dc.subject.otherObesityes_ES
dc.subject.otherL- and S-alleleses_ES
dc.subject.other5HTTLPR polymorphismes_ES
dc.titleAssociation of the 5HTTLPR Polymorphism with Obesity in Mexican Women with High Native American Ancestryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

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