Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2613
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dc.contributor46461es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-1995-1696-
dc.contributor.otherhttps://orcid.org/0000-0001-6803-925X-
dc.coverage.spatialGlobales_ES
dc.creatorMorales Velazquez, Gabriela-
dc.creatorLazalde Ramos, Blanca Patricia-
dc.creatorGómez Meda, Belinda Claudia-
dc.creatorZuñiga González, Guillermo Moisés-
dc.creatorOrtíz García, Yveth Marlene-
dc.creatorGutiérrez Hernández, Rosalinda-
dc.creatorGuerrero Velazquez, Celia-
dc.creatorSánchez de la Rosa, Susana Vanessa-
dc.creatorZamora Pérez, Ana Lourdes-
dc.date.accessioned2021-06-18T17:17:26Z-
dc.date.available2021-06-18T17:17:26Z-
dc.date.issued2019-11-03-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1741-427Xes_ES
dc.identifier.issn1741-4288es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2613-
dc.identifier.urihttps://doi.org/10.48779/xgcn-9k92-
dc.description.abstractJatropha dioica is traditionally used owing to its antiviral, antifungal, and antimicrobial properties. But, toxicological information regarding J. dioica root total extract is currently limited. The aim of this work was to evaluate in a rat model, the transplacental genotoxicity effect of J. dioica aqueous root total extract. Three different J. dioica aqueous root total extract doses (60, 100, and 300 mg/kg) were administered orally to Wistar rats during 5 days through the pregnancy term (16–21 days). Pregnant rats were sampled every 24 h during the last 6 days of gestation, and pubs were sampled at birth. Genome damage in dams and their newborn pups transplacentally exposed to J. dioica was evaluated by in vivo micronuclei assay. We evaluated the frequency of micronucleated erythrocytes (MNE), micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) in peripheral blood samples from pups and MNPCE and PCE in pregnant rats. No genotoxic effect was observed after oral administration of the three different doses of aqueous root total extract of J. dioica in pregnant or in their newborn pubs, after transplacental exposure. A significant decrease in PCE frequency was noted in samples from pubs of rats treated with the highest dose of J. dioica extract. The aqueous total root extract of J. dioica at the highest dose tested in our research do have cytotoxic effect in pups transplacentally exposed to this plant extract. Moreover, neither a genotoxic nor a cytotoxic effect was observed in pregnant rats. In the present work, there was no evidence of genome damage in the rat model after transplacental exposure to J. dioica aqueous root total extract.es_ES
dc.language.isospaes_ES
dc.publisherHindawies_ES
dc.relationhttps://www.hindawi.com/journals/ecam/2019/2962950/es_ES
dc.relation.ispartofhttps://doi.org/10.1155/2019/2962950es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceEvidence-Based Complementary and Alternative Medicine, Volume 2019, Article ID 2962950es_ES
dc.subject.classificationBIOLOGIA Y QUIMICA [2]es_ES
dc.subject.otherJatropha dioicaes_ES
dc.subject.othermicronucleated erythrocytes (MNE)es_ES
dc.subject.othergenome damagees_ES
dc.titleGenome Damage in Rats after Transplacental Exposure to Jatropha dioica Root Extractes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

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