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DC Field | Value | Language |
---|---|---|
dc.contributor | 43665 | es_ES |
dc.contributor | 46461 | es_ES |
dc.contributor.other | https://orcid.org/0000-0002-1995-1696 | - |
dc.creator | Araujo Espino, Diana Isela | - |
dc.creator | Zamora Perez, Ana Lourdes | - |
dc.creator | Zúñiga González, Guillermo Moisés | - |
dc.creator | Gutiérrez Hernández, Rosalinda | - |
dc.creator | Morales Velazquez, Gabriela | - |
dc.creator | Lazalde Ramos, Blanca Patricia | - |
dc.date.accessioned | 2021-06-22T21:00:24Z | - |
dc.date.available | 2021-06-22T21:00:24Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier | info:eu-repo/semantics/publishedVersion | es_ES |
dc.identifier.issn | 0273-2300 | es_ES |
dc.identifier.uri | http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2641 | - |
dc.identifier.uri | https://doi.org/10.48779/hndf-9237 | - |
dc.description.abstract | Jatropha dioica Sessé ex Cerv. is a medicinal plant credited with low cytotoxicity in vitro. Thus, the objective of this work was to evaluate the possible genotoxic and cytotoxic effect in vivo of the J. dioica aqueous extract by means of micronucleus assay in mouse peripheral blood. Four different J. dioica aqueous extract dose-units were evaluated (30, 60, 100, and 300 mg/kg). The extract was administered orally to male Balb-C-strain mice every 24 h during 5 days. Blood samples were taken at 0, 24, 48, 72, 96, and 120 h from the mouse's tail and were performed in duplicate extensions. The number of Polychromatic Erythrocytes (PCE), Polychromatic Micronucleus Erythrocytes (PCEMN), and Micronucleus Erythrocytes (MNE) was determined at the different sampling times in the different study groups. Our results showed that the group that received 60 mg/kg of cyclophosphamide (positive control) presented a significant decrease in the PCE (p = 0.044) proportion and a significant increase in MNE (p = 0.032, p = 0.0001). The groups that received the different J. dioica aqueous extract doses did not present either a PCE decrease or an increase in PCEMN and MNE. J. dioica exerts neither a genotoxic nor a cytotoxic effect on mouse peripheral blood at high doses. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | https://doi.org/10.1016/j.yrtph.2017.03.017 | es_ES |
dc.relation.uri | generalPublic | es_ES |
dc.rights | Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.source | Regulatory Toxicology and Pharmacology Vol. 86, June 2017, Pages 260-264 | es_ES |
dc.subject.classification | BIOLOGIA Y QUIMICA [2] | es_ES |
dc.subject.other | Jatropha dioica Sessé ex Cerv. | es_ES |
dc.subject.other | Genotoxicity | es_ES |
dc.subject.other | Cytotoxicity | es_ES |
dc.subject.other | Micronuclei | es_ES |
dc.subject.other | Erythrocytes | es_ES |
dc.subject.other | Mice | es_ES |
dc.subject.other | Peripheral blood | es_ES |
dc.title | Genotoxic and cytotoxic evaluation of Jatropha dioica Sessé ex Cerv. by the micronucleus test in mouse peripheral blood | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
Appears in Collections: | *Documentos Académicos*-- M. en Ciencias y Tecnología Química |
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