Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2653
Full metadata record
DC FieldValueLanguage
dc.contributor46461es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-1995-1696-
dc.coverage.spatialGlobales_ES
dc.creatorLópez Verdín, Sandra-
dc.creatorSoto Avila, Juan José-
dc.creatorZamora Perez, Ana Lourdes-
dc.creatorLazalde Ramos, Blanca Patricia-
dc.creatorMartínez Fierro, Margarita de la Luz-
dc.creatorGonzález González, Rogelio-
dc.creatorMolina Frechero, Nelly-
dc.creatorIsiordia Espinoza, Mario Alberto-
dc.creatorBologna Molina, Ronell-
dc.date.accessioned2021-06-24T15:48:26Z-
dc.date.available2021-06-24T15:48:26Z-
dc.date.issued2017-11-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1698-4447es_ES
dc.identifier.issn1698-6946es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2653-
dc.identifier.urihttps://doi.org/10.48779/ts62-j113-
dc.description.abstractBackground: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. Material and Methods: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immu-nohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method. Patients without cancer were included in the study as a control group for comparisons of the sE-cadherin levels. Results: sE-cadherin levels in the saliva of patients without cancer were lower than those in patients with cancer, and the difference was statistically significant (p=0.031). Low mE-cadherin expression was statistically signifi-cantly associated with lymph node positivity (p=0.015) and advanced clinical stage (p=0.001). The inverse rela-tionship between mE-cadherin and sE-cadherin was significant in terms of lymph node positivity (p=0.014) and advanced clinical stage (p=0.037). Conclusions: The results suggest that sE-cadherin levels are significantly increased in patients with oral cancer and that its low expression within the membrane as well as the progression of the disease appear to be inversely associ-ated with levels of sE-cadherin in the saliva.es_ES
dc.language.isoenges_ES
dc.publisherMedicina Oral S. L.es_ES
dc.relationhttp://www.medicinaoral.com/medoralfree01/aop/21907.pdfes_ES
dc.relation.ispartofhttp://dx.doi.org/doi:10.4317/medoral.21907es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceMedicina Oral Patologia Oral y Cirugia Bucal. 2017 Nov 1;22 (6):e694-701.es_ES
dc.subject.classificationBIOLOGIA Y QUIMICA [2]es_ES
dc.subject.otherE-cadher.ines_ES
dc.subject.othersalivaes_ES
dc.subject.otheroral canceres_ES
dc.titlePatients with advanced oral squamous cell carcinoma have high levels of soluble E-cadherin in the salivaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

Files in This Item:
File Description SizeFormat 
Lopez Verdin 2017.pdf2,45 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons