Please use this identifier to cite or link to this item:
http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2657
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | 46461 | es_ES |
dc.coverage.spatial | Global | es_ES |
dc.creator | G. Naranjo, María-Eugenia | - |
dc.creator | Rodrigues Soares, Fernanda | - |
dc.creator | Peñas Lledó, Eva M. | - |
dc.creator | Tarazona Santos, Eduardo | - |
dc.creator | Fariñas, Humberto | - |
dc.creator | Rodeiro, Idania | - |
dc.creator | Terán, Enrique | - |
dc.creator | Grazina, Manuela | - |
dc.creator | E. Moya, Graciela | - |
dc.creator | López López, Marisol | - |
dc.creator | Sarmiento, Alba P. | - |
dc.creator | Calzadilla, Luis R. | - |
dc.creator | Ramírez Roa, Ronald | - |
dc.creator | Ortiz López, Rocío | - |
dc.creator | Estévez Carrizo, Francisco E. | - |
dc.creator | Sosa Macías, Martha | - |
dc.creator | Barrantes, Ramiro | - |
dc.creator | LLerena, Adrián | - |
dc.creator | E. Moya, Graciela | - |
dc.creator | Fcrreiro, Verónica | - |
dc.creator | Tarazona Santos, Eduardo | - |
dc.creator | Rodrigues Soares, Fernanda | - |
dc.creator | Scliar, Marilia O. | - |
dc.creator | Gouveia, Mateus H | - |
dc.creator | Sarmiento, Alba P. | - |
dc.creator | Borbón, Angélica | - |
dc.creator | Barrantes, Ramiro | - |
dc.creator | Jiménez Arce, Gerardo | - |
dc.creator | Céspedes Garro, Carolina | - |
dc.creator | Rodeiro, Idania | - |
dc.creator | Álvárez, Mayra | - |
dc.creator | Delgado, René | - |
dc.creator | Remirez, Diadelis | - |
dc.creator | Pérez, Bárbaro | - |
dc.creator | Calzadilla, Luis R. | - |
dc.creator | Terán, Enrique | - |
dc.creator | Hernández, Francisco | - |
dc.creator | Terán, Santiago | - |
dc.creator | Ortiz López, Rocío | - |
dc.creator | Rojas Martinez, Augusto | - |
dc.creator | Garza Ocañas, Lourdes | - |
dc.creator | Pérez Páramo, Yadira X. | - |
dc.creator | López López, Marisol | - |
dc.creator | Ortega Vázquez, Alberto | - |
dc.creator | Monroy Jaramillo, Nancy | - |
dc.creator | Jung Cook, Helgi | - |
dc.creator | Fricke Galindo, Ingrid | - |
dc.creator | Sosa Macías, Martha | - |
dc.creator | Galaviz Hernández, Carlos | - |
dc.creator | Lares Aseff, Ismael | - |
dc.creator | Lazalde Ramos, Blanca P. | - |
dc.creator | Ramírez Roa, Ronald | - |
dc.creator | Altamirano Tinoco, Catalina | - |
dc.creator | Tarazona Santos, Eduardo | - |
dc.creator | Zamudio, Roxana | - |
dc.creator | Gilman, Robert H. | - |
dc.creator | Grazina, Manuela | - |
dc.creator | LLerena, Adrián | - |
dc.creator | Cobaleda, Jesús | - |
dc.creator | de Andrés, Fernando | - |
dc.creator | Dorado, Pedro | - |
dc.creator | Fariñas, Humberto | - |
dc.creator | Naranjo, Eugenia G. | - |
dc.creator | Peñas Lledó, Eva M. | - |
dc.creator | Estévez Carrizo, Francisco E. | - |
dc.date.accessioned | 2021-06-24T20:44:49Z | - |
dc.date.available | 2021-06-24T20:44:49Z | - |
dc.date.issued | 2018-09-18 | - |
dc.identifier | info:eu-repo/semantics/publishedVersion | es_ES |
dc.identifier.issn | 1536-2310 | es_ES |
dc.identifier.issn | 1557-8100 | es_ES |
dc.identifier.uri | http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2657 | - |
dc.description.abstract | Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations in CYP2D6, CYP2C9, and CYP2C19 drug metabolizing enzyme genotypes, which were subsequently utilized to catalog their "predicted drug metabolism phenotypes" across Native American and Ibero American populations. Importantly, we report in this study, a total of 6060 healthy individuals from Ibero-America who were classified according to their self-reported ancestry: 1395 Native Americans, 2571 Admixed Latin Americans, 96 Afro-Latin Americans, 287 white Latin Americans (from Cuba), 1537 Iberians, and 174 Argentinean Ashkenazi Jews. Moreover, Native Americans were grouped into North-, Central-, and South Amerindians (from Mexico, Costa Rica, and Peru, respectively). All subjects were studied for the most common and functional CYP2D6, CYP2C9, and CYP2C19 allelic variants, and grouped as genotype-predicted poor or ultrarapid metabolizer phenotypes (gPMs and gUMs, respectively). Native Americans showed differences from each ethnic group in at least two alleles of CYP2D6, CYP2C9, and CYP2C19. Native Americans had higher frequencies of wild-type alleles for all genes, and lower frequency of CYP2D6*41, CYP2C9*2, and CYP2C19*17 (p < 0.05). Native Americans also showed less CYP2C19 gUMs than the rest of the population sample. In addition, differences within Native Americans (mostly North vs. South) were also found. The interethnic differences described supports the need for population-specific personalized and precision medicine programs for Native Americans. To the best of our knowledge, this is the largest study carried out in Native Americans and other Ibero-American populations analyzing CYP2D6, CYP2C9, and CYP2C19 genetic polymorphisms. Population pharmacogenomics is a nascent field of global health and warrants further research and education. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Mary Ann Liebert, Inc. | es_ES |
dc.relation | https://home.liebertpub.com/publications/omics-a-journal-of-integrative-biology/43 | es_ES |
dc.relation.ispartof | 10.1089/omi.2018.0114 | es_ES |
dc.relation.uri | generalPublic | es_ES |
dc.rights | Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América | * |
dc.rights | Atribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.source | OMICS: A Journal of Integrative Biology Vol. 25, No. 6 | es_ES |
dc.subject.classification | BIOLOGIA Y QUIMICA [2] | es_ES |
dc.subject.other | Amerindians | es_ES |
dc.subject.other | CYP2C19 | es_ES |
dc.subject.other | CYP2C9 | es_ES |
dc.subject.other | CYP2D6 | es_ES |
dc.subject.other | Latin Americans | es_ES |
dc.subject.other | drug metabolism | es_ES |
dc.subject.other | pharmacogenetics | es_ES |
dc.subject.other | precision medicine | es_ES |
dc.title | Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
Appears in Collections: | *Documentos Académicos*-- M. en Ciencias y Tecnología Química |
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