Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2658
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dc.contributor46461es_ES
dc.contributor.otherhttps://orcid.org/0000-0002-1995-1696-
dc.coverage.spatialGlobales_ES
dc.creatorZamora Pérez, Ana Lourdes-
dc.creatorOrtíz García, Yveth Marlene-
dc.creatorLazalde Ramos, Blanca Patricia-
dc.creatorGuerrero Velazquez, Celia-
dc.creatorGómez Meda, Belinda Claudia-
dc.creatorRamírez Aguilar, Miguel Angel-
dc.creatorZuñiga González, Guillermo Moisés-
dc.date.accessioned2021-06-24T20:55:06Z-
dc.date.available2021-06-24T20:55:06Z-
dc.date.issued2014-03-25-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1600-0765es_ES
dc.identifier.urihttp://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/2658-
dc.identifier.urihttps://doi.org/10.48779/cq6c-vq34-
dc.description.abstractBackground and objective Periodontal disease is a chronic bacterial infection characterized by connective tissue breakdown and alveolar bone destruction because of inflammatory and immune response caused by periodontopathogens and long-term release of reactive oxygen species. A high number of reactive oxygen species result in periodontal tissue damage through multiple mechanisms such as lipid peroxidation, protein denaturation and DNA damage. The aim of this study was to evaluate DNA and oxidative damage in subjects with chronic or aggressive periodontitis and healthy controls. Material and methods Buccal mucosa cells and whole saliva were collected from 160 subjects, who were divided into three groups: subjects with chronic periodontitis (CP) (n = 58), subjects with aggressive periodontitis (AgP) (n = 42) and a control group (n = 60). DNA damage was determined by counting micronuclei (MN) and nuclear abnormalities (NAs) in exfoliated cells, including binucleated cells, cells with nuclear buds and karyolitic, karyorrhectic, condensed chromatin and pyknotic cells. The degree of oxidative stress was determined by quantifying 8-hydroxy-2'-deoxyguanosine (8-OHdG) in whole saliva. Results Subjects with CP or AgP presented significantly more ( p < 0.05) MN and NAs and higher levels of 8-OHdG ( p < 0.05) compared with the control group. Conclusion Our results indicate that subjects with periodontitis (CP or AgP) exhibited an increase in the frequency of MN, NAs and 8-OHdG, which is directly related to DNA damage. In addition, a positive correlation exists between oxidative stress produced by periodontitis disease and MN.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationhttps://onlinelibrary.wiley.com/doi/abs/10.1111/jre.12175es_ES
dc.relation.ispartofhttps://doi.org/10.1111/jre.12175es_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceJournal of Periodontal Research, 25 Mar 2014, 50(1):28-36es_ES
dc.subject.classificationBIOLOGIA Y QUIMICA [2]es_ES
dc.subject.otherPeriodontal diseasees_ES
dc.subject.otherchronic bacterial infectiones_ES
dc.subject.otherBuccal mucosa cellses_ES
dc.titleIncreased micronuclei and nuclear abnormalities in buccal mucosa and oxidative damage in saliva from patients with chronic and aggressive periodontal diseaseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- M. en Ciencias y Tecnología Química

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