Please use this identifier to cite or link to this item: http://ricaxcan.uaz.edu.mx/jspui/handle/20.500.11845/698
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dc.contributor120273es_ES
dc.contributor.otherhttps://orcid.org/0000-0003-1324-4488-
dc.coverage.spatialGlobales_ES
dc.creatorMuñoz Carrillo, José Luís-
dc.creatorMuñoz Escobedo, José Jesús-
dc.creatorMaldonado Tapia, Claudia-
dc.creatorChávez Ruvalcaba, Francisca-
dc.creatorMoreno García, María Alejandra-
dc.date.accessioned2019-02-28T18:13:26Z-
dc.date.available2019-02-28T18:13:26Z-
dc.date.issued2017-
dc.identifierinfo:eu-repo/semantics/publishedVersiones_ES
dc.identifier.issn1365-3024es_ES
dc.identifier.urihttp://localhost/xmlui/handle/20.500.11845/698-
dc.identifier.urihttps://doi.org/10.48779/40q9-0294-
dc.description.abstractDuring the course of infection with Trichinella spiralis, an inflammatory response is triggered at the intestinal level in the host, playing a crucial role in the expulsion and elimination of the parasite. However, several studies have demonstrated that this inflammatory response is harmful to the host; hence, the importance of studying molecules with therapeutic potential like resiniferatoxin, which is known to have an anti-inflammatory effect both in vitro and in vivo. In this article, we evaluated the anti-inflammatory activity of resiniferatoxin during the intestinal phase of T. spiralis infection by quantitatively determining the levels of TNF-α, NO and PGE2 as well as the percentage of eosinophils in the blood and intestinal pathology. In addition, parasite burden was determined during the muscle infection. Our results show that resiniferatoxin lowered the serum levels of TNF-α, NO and PGE2, as well as the percentage of eosinophils in the blood and intestinal pathology during the intestinal infection. Moreover, resiniferatoxin also lowered the parasite burden in muscle, resulting in a reduction of the humoral response (IgG) associated to treatment with resiniferatoxin. These findings suggest a potential therapeutic use of the anti-inflammatory effect of resiniferatoxin, which also contributes to host defence against the challenge of T. spiralis infection.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationwileyonlinelibrary.com/journal/pimes_ES
dc.relation.urigeneralPublices_ES
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Estados Unidos de América*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceParasite Immunology Vol. 39, No. 1, pp. 1-14es_ES
dc.subject.classificationBIOLOGIA Y QUIMICA [2]es_ES
dc.subject.othereosinophiliaes_ES
dc.subject.otherinflammationes_ES
dc.subject.otherresiniferatoxines_ES
dc.subject.otherTrichinella spiralises_ES
dc.titleResiniferatoxin lowers TNF-α, NO and PGE2 in the intestinal phase and the parasite burden in the muscular phase of Trichinella spiralis infectiones_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Appears in Collections:*Documentos Académicos*-- UA Ciencias Biológicas

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